Synthesis of 4,10-Dinitro-2,6,8,12-Tetraoxa-4, 10-Diazatetracyclo-5.5.0.0^5,90^3,11-Dodecane

This paper studies two-step synthetic process of TEX (4,10-dinitro-2,6, 8,12-tetraoxa-4, 10-diazatetracyclo-5.5.0.0^5,90^3,11-dodecane) and the effects of key factors on the yield of DFTHP (intermediate) and TEX. The results show that the yield of DFTHP could reach to 68.3% when the adjusted pH value of reaction solution reaches to 9 by saturated NaOH solution. When the volume ratio of fuming HNO₃ to concentrated H₂SO₄ is 3∶2, and the ratio of nitrating agent (mL) to DFTHP(g) is 3:1, the yield of TEX raises to 59.7% . The optimized overall yield of TEX obtained from two-step synthetic process could be 40.8%.