Abstract: To avoid considerable of expensive real driving experiments, the indoor simulation experiments on driving were studied. Twenty-two people were selected as experimental subjects, and the fatigue scale and the experimental psychology instruments were used in the indoor simulation experiments on the high-seed road section, the mountain road section and the prairie road section, in order to study the psychological impact of different landscape environment. The statistics of the fatigue scale and the results of experimental psychology instruments show that the psychological impact on the subjects is different based on different road environment. Moreover, moderate lines/shapes and favorable road landscapes can delay the fatigue phenomenon of the subjects.