Abstract: Several new hyaluronic metal complexes were synthesized with the sodium hyaluronate as raw material. The properties of synthesized complexes were characterized by IR, ¹HNMR, EDX and elemental analysis. The preliminaries of anticancer activities in vitro on human uterine cancer cells demonstrate that a few of new hyaluronic metal complexes have better anticancer activity than that of the background sodium hyaluronate.