Abstract: To simulate the complete procedure efficiently for the explosively-formed projectile (EFP) being formed, flying in the air and penetrating into alumina ceramic/metal composite target in the condition of high stand-off, the material properties of the 99 alumina ceramic were described by JH-2 constitute model, the moving mesh method was used for the computing flow field and the EFP penetrating into alumina ceramic/steel composite target was simulated with the fluid-structure interaction arithmetic. The computation time decreased greatly with the moving meth method due to the less number of meshes. The residual penetration depths in the A3 steel back plates were acquired. The results indicate that the tip speed of the EFP is consistent with the test result and the rear speed of the EFP is a little higher than the test. Thus the residual penetration depths are a little deeper than the test results. The residual penetration depths acquired both by the tests and by the simulations decrease with the increase of ceramic thickness. There is a nearly linear relationship between the residual penetration depths and the thickness of the ceramics.