Abstract: To meet the needs of reducing the impact sensitivity and improving the safety of melting-cast explosives containing HMX or RDX, created a formulation design method of insensitive explosive based on the rule of maximum entropy. With this method, insensitive explosive formulations that are powerful and safe could be achieved. Choose the explosive formulations of NQ/HMX/TNT-36.1/33.9/30.0 and NQ/RDX/TNT-34.5/25.5/40.0 to make two experimental samples, and tested these samples' detonation velocity and rifle shooting sensitivity. Experimental results show that, the detonation velocity only reduces 2% to 4% but it is much more insensitive in rifle shooting experiment, compared with Octol 70/30 and Cyclotol 60/40. It means that these two samples become much safer with a little energy reduce, that proves the formulation design method which created in this article is feasible.