Abstract: For the complex nonlinear system, an input-output data based intelligent control scheme is proposed by means of combining multiple models modeling and fractional PID control. Firstly, on-line modeling for the nonlinear system is done by using the input-output data; and then, a weighted control method is employed to design the fractional PID controller. The proposed method combines the modeling and control in one framework so as to increase the robustness of the control system. Simulation result shows the effectiveness of the proposed scheme.