Abstract: In order to determine the effects of fullerene and its water-soluble derivatives on mammal oocyte meiosis,a water-soluble phosphonic acid derivative of fullerene(2P),fullerene-PVP solution and fullerenol were used to act on mouse GV stage and superovulated oocytes in vitro under irradiation.The maturation and activation of the oocytes were determined by their first polar body rate and pronuclear rate,respectively.The results indicated that fullerene-PVP solution and fullerenol have no obvious effect on oocyte in vitro maturation;but that 2P inhibits the oocyte maturation and parthenogenetic activation under irradiation.The effect of 2P was dose-dependent.