Abstract: In order to effectively characterize the propagation law of explosion shock waves from various explosion sources in multi-right-angle turning tunnels under negative pressure conditions, based on the multi-media flow numerical calculation model, the propagation characteristics of explosion sources such as CL-20, emulsion explosives and gas in single/double right-angle turning tunnels under negative pressure environments were analyzed. The results showed that increase in the number of right-angle turns effectively reduced peak overpressure of the shock wave and prolonged the formation position of the plane wave. Under the same tunnel structure conditions, as energy released by the explosion source increased, the attenuation efficiency of shock wave gradually increased, while the influence of initial environmental pressure on the attenuation efficiency was not obvious. Based on Sachs’ proportionality law and dimensional analysis, combined with the corresponding attenuation efficiency coefficient, a correlation model of shock wave overpressure peak was extended and established, which extends the data of normal pressure long straight tunnels to the situation of multiple explosion sources in multi-right-angle turning tunnels under negative pressure conditions, providing a reference for the safety design of production and military protection in high-altitude environments.