Abstract: In response to the security and privacy challenges of multi-node distributed inference in satellite networks, a collaborative and trustworthy distributed inference technology for space-based intelligent models was investigated. Firstly, a space-based intelligent model inference system was constructed based on leveraging block chain technology, considering cloud nodes and clusters of edge satellite nodes. And then, a method was proposed for the collaborative and trustworthy distributed inference of space-based intelligent models. In the preparation stage, an adaptive segmentation for the models was performed based on load balancing and minimal latency considerations. During the inference stage, a blockchain technology was adopted to realize the collaborative and credible cluster inference. Experimental results demonstrate that the proposed system and method can achieve the safe and efficient distributed inference of intelligent models, thereby supporting the application of intelligent models in satellite scenarios.