Abstract: In order to explore the propagation law of radial shock wave in porous cancellous bone and pore fluid, a cancellous bone model was established based on CT image 3D reconstruction and Voronoi tessellation design with different bone volume fractions, developing radial shock wave device, soft tissue layer, cortical bone and bone marrow, as well as carrying out display dynamics simulation analysis based on a finite element fluid-structure coupling method. The results show that the model can simulate the propagation characteristics of radial shock wave through soft tissue layer in cancellous bone and pore fluid. In the cancellous bone region near the cortical bone there is more evidence stress, and there are also changes of pressure and flow velocity in the pore fluid. Increasing the shock wave driving pressure and decreasing the bone volume fraction of cancellous bone will increase the pressure and effective stress of bone trabeculae, and the force and flow velocity of pore fluid will also increase. The results provide an idea and method for the finite element simulation of orthopedic diseases by radial shock wave, and also provide an important reference for the treatment of orthopedic diseases by extracorporeal shock wave.