Abstract: In order to study the energy release behavior of Al-PTFE reactive materials, a numerical method including initiation criterion and reaction rate equation was developed based on the theoretical model for impact-initiated chemical reaction of reactive materials. Energy release experiments of reactive materials in the airtight chamber were carried out to verify the effectiveness of this numerical method and make a quantitative analysis of the flying and reaction process of reactive fragments. Results show that the reaction process in the simulation is consistent with the trend of flame in the experiment, and the average difference of released energy between simulation and experimental results is 26.3%, implying that the method can relatively well reproduce the impact-initiated energy release behavior of reactive materials. Energy release process of reactive materials can be divided into three stages: platform stage, rising stage and falling stage. The released energy and chemical reaction rate increase rapidly with the increase of impact speed.