Abstract: Since the traditional damage effect calculation method of the non-uniform area target needs to re-do the Monte-Carlo simulation after the position of sub-target changes, a damage effect modeling method of area target based on the damage effect function was proposed. This function reflects the distribution of ammunition power field in space from the perspective of damage probability, and is not affected by the position change of sub-targets. Drawing on the idea of informatics and integral transformation, the convolution integral calculation of the damage effect function was converted into matrix convolution calculation, and the computational complexity was changed from O(N²) to O(NlbN) with the help of two-dimensional fast Fourier transformation, which greatly improved the calculation efficiency and reduced the calculation time from the minute level of Monte-Carlo simulation to the second level. The damage effect of integral blasting missile warhead on typical airport apron targets under specific combat scenarios and different strike schemes was empirically studied, and the feasibility of the calculating method was verified.