Abstract: In this paper, an optimization design was carried out based on Box-Behnken method for the formula of dust restrain reagent. Picking APG-10, SDBS and APAM as response variables, taking sedimentation time and transmission rate as response values, a regression model was established to get an optimization compound proportion of surfactant and additive for dust restrain reagent modulation. Experiment results show that, when the correlation coefficient R₂ is 0.9082 in the regression model of reagent and sedimentation time, the F value of the equation is 7.69 and the probability is 0.0068<0.01. And when the correlation coefficient R₂ is 0.9190 in the regression model of reagent and transmission rate, the F value of the equation is 8.83 and the probability is 0.0045<0.01. The conclusion is that, the best compounding concentration is 0.17% APG-10, 0.49% SDBS and 0.05% APAM, the predicted settlement time is 34.9025 s, and the predicted transmittance is 93.7259%, reaching the optimum state of wetting and agglomeration.