Abstract: Space-frequency adaptive processing (SFAP) is widely used in satellite navigation reception and processing for its ideal anti-jamming ability. However, the conventional SFAP can cause pseudo-range bias and carrier phase bias of the navigation signal, which cannot meet the requirements of high-precision differential positioning. To solve this problem, an algorithm was proposed based on array response to suppress the measurement bias of SFAP. By calculating the array response of the center frequency of each bin, the phase of the array response was calibrated, and the amplitude of the array response was remained unchanged, not only reducing the influence of SFAP on the measurement accuracy, but also unchanging the null position and depth of the array synthesis pattern. This algorithm can both suppress the pseudo-range bias and carrier phase bias, and there is no influence on the degree of freedom and the anti-jamming ability. Due to the above advantages, the algorithm can meet the requirements of high-precision positioning in strong interference condition. Theoretical analysis and simulation results verify the effectiveness of the algorithm.