Abstract: Aiming at the quantity research on the impact/deflagration behavior of reactive materials, the user subroutines of equation of state (EOS), ignition model and overall reaction ratio were edited and compiled based on the secondary development function of AUTODYN codes, and then the numerical simulation on impact/deflagration behavior by reactive materials projectile during high speed penetration was conducted. Based on the numerical simulation of high-speed collision of Al/PTFE reactive materials projectile with 2024 aluminum spacer plate, the morphologic evolution of Al/PTFE reactive materials fragments was obtained, and the variation of reaction ratio, pressure and temperature of reactive materials particle versus time during the impact event were extracted, so that the quantity research on the impact/deflagration behavior of reactive materials was achieved. The simulation results show that the trend of overall reaction ratio calculated with time is well consistent with the deflagration flame in experiments, and the temperature is compatible with previous research, implying that the proposed simulation method can reproduce the impact and energy release process by Al/PTFE reactive materials projectile at a high level.