Abstract: According to the requirements of ventilation condition monitoring for large-scale farms, a system of wind-induced vibration piezoelectric harvesting energy was designed to solve the self-powered problem of monitoring sensors. The self-powered system consists of piezoelectric energy harvesting structure and energy management circuit, and that can convert wind energy into electricity. The results of the analysis and testing indicate that the piezoelectric energy harvesting structure could output 10.88 V voltage and 6.975 mW power. The results of LTspice simulation show that the energy management circuit based on LTC3588-1 could realize the function of voltage conversion and output 3.3 V voltage stably. According to the similarity between mechanical system and electrical system, the overall model of the self-powered system was built, the simulation results of Matlab/Simulink show that the piezoelectric energy harvesting structure could output 10.87 V voltage and 6.989 mW power, and the end self-powered system could output 3.3 V voltage. All the above results are basically consistent with the simulation and test results of energy harvesting structure and energy management circuit, indicating that the overall modeling of the system is correct and the scheme is reasonable. Through the field test, when the wind speed was 2.6 m/s at the vent, the self-powered system could output 3.3 V voltage, and supply power to the sensor monitoring system stably. This study can be used in the ventilation monitoring sensor self-powered system widely.